Keep track of Carefully (one)mitotane decreases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Mitotane is usually a strong inducer of cytochrome P-4503A4; watch when coadministered with CYP3A4 substrates for attainable dosage adjustments.Drugs which will blunt the growth hormone (GH) respon